Related Experiment Video
Updated: Oct 6, 2025
07:39
SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
Published on: June 28, 2019
24.3K
[Oncology in Super-Aged Society].
Fumio Nagashima1, Kentaro Enomoto, Junji Furuse
1Dept. of Medical Oncology, Kyorin University Faculty of Medicine.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|January 20, 2022
Summary
Japan
Area of Science:
- Geriatric Oncology
- Public Health
- Gerontology
Background:
- Japan's population aged 65+ is 29%, with rising elderly cancer cases.
- The International Society of Geriatric Oncology prioritizes education, care, research, and partnerships.
- Japan's 3rd Basic Plan for Cancer Control includes "cancer in the elderly."
Purpose of the Study:
- To address the growing need for geriatric oncology in Japan's super-aged society.
- To highlight Japan's initiatives in cancer care for the elderly.
- To discuss challenges and potential global contributions from Japan's experience.
Main Methods:
- Review of Japan's national cancer control plans and geriatric oncology initiatives.
- Analysis of demographic trends and social security implications.
- Discussion of interdisciplinary cooperation and support systems.
Main Results:
- Publication of "Guidelines for Cancer Chemotherapy for the Elderly" in Japan.
- Ongoing social security reforms due to an aging population.
- Emphasis on enhancing cooperation between oncology and geriatrics.
Conclusions:
- Japan's experience as a super-aged society offers valuable insights for global geriatric oncology.
- Strengthening collaboration between medical fields and support systems is crucial.
- Long-term strategic planning is essential for addressing the challenges of an aging population.
More Related Videos
Related Concept Videos
01:26Aging
287
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
287
01:19The Effect of Aging on Tissues
2.8K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.8K
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
13
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
13
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
8
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
8
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
3
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
3
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
9
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
9