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Updated: Oct 6, 2025
08:09
Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood
Published on: February 11, 2017
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A Transdiagnostic Perspective on Youth Irritability.
Daniel N Klein1, Lea R Dougherty2, Ellen M Kessel3
1Department of Psychology, Stony Brook University.
Current Directions in Psychological Science
|January 20, 2022
Summary
Irritability in youth is a growing concern, predicting various disorders. Genetic, environmental, and brain circuit factors, influenced by age, contribute to its development and outcomes.
Area of Science:
- Child and Adolescent Psychiatry
- Developmental Psychology
- Neuroscience
Background:
- Irritability is a significant clinical issue in youth, linked to multiple diagnoses.
- It predicts the development of a wide spectrum of psychiatric disorders.
- Understanding the factors contributing to youth irritability is crucial for early intervention.
Purpose of the Study:
- To explore the etiopathogenesis of irritability in youth.
- To investigate the roles of genetic, environmental, and neural factors.
- To examine how age-dependent effects and regulatory systems influence irritability outcomes.
Main Methods:
- Review of existing research on the genetic and environmental factors in youth irritability.
- Analysis of studies on reward and cognitive control circuitry abnormalities.
- Examination of the influence of threat-responsive self-regulatory systems.
Main Results:
- Genetic and family environmental factors are implicated in youth irritability.
- Abnormalities in reward and cognitive control circuitry are associated with irritability.
- Age-dependent effects and the nature of irritability (tonic vs. phasic) influence internalizing versus externalizing outcomes.
Conclusions:
- Irritability in youth is a complex issue with multifactorial origins.
- Age-dependent neurobiological and environmental factors are key.
- Understanding regulatory systems is vital for predicting disorder trajectories.
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