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Metabolomics Analysis on Obesity-Related Obstructive Sleep Apnea After Weight Loss Management: A Preliminary Study
Weijun Huang1, Anyuan Zhong2, Huajun Xu1
1Department of Otorhinolaryngology Head and Neck Surgery and Otolaryngology Institute of Shanghai Jiao Tong University and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Roux-en-Y gastric bypass (RYGB) surgery significantly improves metabolic status and obstructive sleep apnea (OSA) in obese patients. Preoperative factors can predict RYGB
Area of Science:
- Metabolomics
- Bariatric Surgery
- Sleep Medicine
Background:
- Obesity and obstructive sleep apnea (OSA) are significant health concerns.
- Roux-en-Y gastric bypass (RYGB) is an effective weight loss surgery.
- RYGB may improve obesity-related OSA.
Purpose of the Study:
- Investigate the metabolomic changes after RYGB in obese patients with OSA.
- Assess the impact of RYGB on metabolic and sleep parameters.
- Identify predictors of RYGB efficacy for OSA remission.
Main Methods:
- Collected clinical, metabolic, and polysomnography (PSG) data at baseline and 6 months post-RYGB.
- Utilized ultra-performance liquid chromatography-mass spectrometry for metabolomic analysis.
- Analyzed changes in serum metabolites and OSA parameters.
Main Results:
- RYGB significantly improved metabolic outcomes and sleep parameters in obese patients with OSA and T2DM.
- Specific metabolite changes (decreased valine, isoleucine; increased trimethylamine N-oxide, hippurate) were observed in OSA remission.
- Preoperative factors (age, AHI, C-peptide, hippurate) accurately predicted RYGB effect size (AUC 0.947).
Conclusions:
- RYGB surgery offers significant metabolic and OSA improvements in obese patients.
- Preoperative assessment of age, AHI, C-peptide, and hippurate can predict RYGB effectiveness.
- Further research is needed to elucidate the mechanisms driving OSA remission post-RYGB.
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