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Targeting Reactive Oxygen Species in Atherosclerosis via Chinese Herbal Medicines

Leyi Zhang1,2, Jiaqin Huang2,3, Danli Zhang2,3

  • 1University Postgraduate Education of Principles and Practice of Traditional Chinese Medicine, Medical University of Vienna, 1090 Vienna, Austria.

Oxidative Medicine and Cellular Longevity
|January 20, 2022
PubMed

Insights

Cardio-cerebrovascular diseases are a leading cause of death, with atherosclerosis driven by oxidative stress. Chinese herbal medicines show potential in treating atherosclerosis by regulating reactive oxygen species (ROS).

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Oxidative Stress Research

Background:

  • Cardio-cerebrovascular disease (CCVD) is a primary cause of mortality, exacerbated by global population aging.
  • Atherosclerosis, a common pathology in CCVDs, is increasingly linked to oxidative stress from excessive reactive oxygen species (ROS) production.
  • Chinese herbal medicine (CHM) is recognized for its health contributions and is explored for auxiliary treatment of atherosclerosis.

Purpose of the Study:

  • To review the mechanisms of reactive oxygen species (ROS) regulation in atherosclerosis.
  • To analyze the therapeutic role of Chinese herbal medicines (CHMs) in atherosclerosis treatment by targeting ROS.

Main Methods:

  • Literature review focusing on the role of ROS in atherosclerosis.
  • Analysis of studies investigating CHMs' effects on intracellular ROS levels.
  • Synthesis of evidence on CHM's anti-atherosclerosis properties related to ROS modulation.

Main Results:

  • Oxidative stress via ROS is a key mechanism in atherosclerosis development.
  • CHMs demonstrate potential in modulating intracellular ROS.
  • CHMs exhibit various anti-atherosclerosis effects through ROS regulation, although mechanisms require further elucidation.

Conclusions:

  • Understanding ROS regulation is crucial for atherosclerosis treatment.
  • CHMs offer a promising avenue for atherosclerosis management by targeting ROS.
  • Further research into CHM mechanisms can optimize their clinical application in CCVDs.

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