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Sodium ozagrel and atorvastatin for type 2 diabetes patients with lacunar cerebral infarction
1Department of Pharmacy, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China.
Insights
Combining sodium ozagrel with atorvastatin significantly improved outcomes for type 2 diabetes patients with lacunar cerebral infarction. This combination therapy reduced inflammation and improved neurological function compared to atorvastatin alone.
Area of Science:
- Cardiology
- Neurology
- Endocrinology
Background:
- Atherosclerosis, a chronic inflammatory disease, is the primary cause of cerebral infarction.
- Current treatments focus on anti-platelet aggregation and improving blood status, with limited efficacy in addressing underlying pathology.
- Type 2 diabetes exacerbates the risk and severity of lacunar cerebral infarction.
Purpose of the Study:
- To evaluate the combined therapeutic effect of sodium ozagrel and atorvastatin in patients with type 2 diabetes and lacunar cerebral infarction.
- To assess the impact of this combination therapy on inflammatory markers, glycemic control, lipid profiles, and neurological function.
Main Methods:
- Eighty-two patients with type 2 diabetes and lacunar cerebral infarction were divided into two groups: control (atorvastatin) and observation (sodium ozagrel + atorvastatin).
- Key outcome measures included the National Institutes of Health Stroke Scale (NIHSS) score, Activities of Daily Living (ADL) score, blood glucose, lipid levels, inflammatory factors (e.g., hs-CRP, IL-1β, TNF-α), HMGB1, PON-1, ESR, MIF, platelet aggregation, and plasma viscosity.
- Data were collected before and after treatment, with analysis of total effective rates and adverse reactions.
Main Results:
- The observation group demonstrated a significantly higher total effective rate (94.00%) compared to the control group (80.00%).
- Combination therapy led to significant improvements in blood glucose, lipid profiles, inflammatory markers, HMGB1, PON-1, MIF, ESR, platelet aggregation, and plasma viscosity compared to atorvastatin alone.
- Patients receiving sodium ozagrel and atorvastatin showed significantly lower NIHSS scores and higher ADL scores post-treatment.
Conclusions:
- Sodium ozagrel in combination with atorvastatin is effective in reducing inflammatory reactions in type 2 diabetes patients with lacunar cerebral infarction.
- This combination therapy helps regulate inflammatory markers (ESR, HMGB1, PON-1, MIF), control blood glucose and lipids, and improve neurological function.
- The combined treatment alleviates nerve injury without increasing the adverse effects associated with atorvastatin monotherapy.
Background:
The main pathological factor of cerebral infarction is atherosclerosis, which is the pathological process of chronic inflammatory diseases such as vascular smooth muscle hyperplasia, inflammatory cell infiltration, extracellular matrix increase, and thrombosis. At present, the focus of clinical treatment is anti-platelet aggregation and improving blood status, and current research is limited to improving symptoms only.
Aim:
To observe the effect of sodium ozagrel and atorvastatin on type 2 diabetes patients with lacunar cerebral infarction.
Methods:
Eighty-two patients with type 2 diabetes and lacunar cerebral infarction admitted to our hospital from January 2018 to February 2020 were equally categorized into two groups according to their treatment method. The control group was administered atorvastatin, and the observation group was administered sodium ozagrel combined with atorvastatin. The National Institutes of Health stroke scale (NIHSS) score, activities of daily living (ADL) score, blood glucose, lipid levels, inflammatory factors, high-mobility group box 1 (HMGB1) levels, paraoxonase-1 (PON-1) levels, erythrocyte sedimentation rate (ESR), and macrophage migration inhibitory factor (MIF) levels were recorded before and after treatment. The total effective rate and adverse reaction rate of the two groups were analyzed.
Results:
The total effective rate of the observation group (94.00%) was significantly higher than that of the control group (80.00%) (χ 2 = 3.998; P = 0.046). The blood glucose indexes, total cholesterol levels, triglyceride levels, low-density lipoprotein cholesterol levels, high-sensitivity C-reactive protein levels, interleukin-1β levels, tumor necrosis factor-α levels, HMGB1 Levels, ESR, MIF levels, platelet aggregation rates, and plasma viscosity of the two groups decreased after treatment; however, high-density lipoprotein cholesterol and PON-1 Levels increased after treatment. After treatment, the blood glucose indexes; blood lipid indexes; inflammatory factors; HMGB1, PON-1, and MIF levels; ESR; platelet aggregation rate; and plasma viscosity of the observation group were better than those of the control group (P < 0.05). After treatment, all patients in the observation group had higher ADL scores and lower NIHSS scores than those in the control group (P < 0.05).
Conclusion:
Sodium ozagrel with atorvastatin can reduce inflammatory reactions; regulate ESR and HMGB1, PON-1, and MIF levels; control blood glucose and lipid indexes; and alleviate nerve injury without increasing adverse effects of atorvastatin alone.
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