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Acute Pancreatitis Due to COVID-19 Active Infection
Frank H Annie1, Julton Chumbe2, Lauren Searls2
1Cardiology, Charleston Area Medical Center (CAMC), Charleston, USA.
Insights
Patients with COVID-19 who developed acute pancreatitis experienced significantly higher mortality, stroke, and hospital admission rates, including ICU stays. This highlights a critical association between pancreatitis and severe outcomes post coronavirus disease 2019 infection.
Area of Science:
- Infectious Diseases
- Gastroenterology
- Critical Care Medicine
Background:
- Investigates the link between coronavirus disease 2019 (COVID-19) and acute pancreatitis.
- Utilizes large registry data to assess the association between acute pancreatitis and mortality in COVID-19 patients.
Purpose of the Study:
- To determine the impact of acute pancreatitis on mortality and other adverse outcomes in patients with COVID-19.
- To analyze large-scale data for associations between post-COVID-19 acute pancreatitis and patient outcomes.
Main Methods:
- Adult patients (18-90 years) with COVID-19 were identified from the TriNetX database (Jan 2020 - June 2021).
- Two cohorts were created: those with post-acute pancreatitis (n=1,173) and those without (n=1,038,515).
- A 1:1 propensity score match was performed, resulting in two well-matched cohorts (n=1,173 each).
Main Results:
- Patients with acute pancreatitis showed higher mortality (12.4% vs 3.7%, p<0.001).
- Increased rates of stroke (3.6% vs 1.7%, p=0.005), inpatient admissions (28.2% vs 10.6%, p<0.001), and ICU admissions (9.5% vs 3.2%, p<0.001) were observed in the pancreatitis group.
Conclusions:
- Acute pancreatitis is associated with significantly worse outcomes in COVID-19 patients.
- Higher mortality, stroke incidence, and hospitalization rates (including ICU) are linked to pancreatitis in the post-COVID-19 setting.
- Findings underscore the importance of monitoring for pancreatitis in COVID-19 patients.
Abstract:
Background This study investigates the relationship between coronavirus disease 2019 (COVID-19) infection and acute pancreatitis. We present large registry data assessing the association between acute pancreatitis and mortality in patients with COVID-19 post-infection. Methods The researchers identified adult patients aged 18-90 years with COVID-19 infections in the TriNetX (COVID-19 research network) database between January 20, 2020, and June 1, 2021. The researchers identified n=1,039,688 cases divided into two cohorts: those with post-acute pancreatitis (n= 1,173) and those without post-acute pancreatitis (n=1,038,515) post COVID-19 infection having follow-up within a two-week period. The researchers then conducted a 1:1 propensity score match to account for differences in the cohorts and created two well-matched cohorts (n=1,173/1,173). Results Patients that developed acute pancreatitis had higher mortality (12.4% vs 3.7%, p<0.001), stroke (3.6% vs 1.7%, p=0.005), higher inpatient admissions (28.2% vs 10.6%, p<0.001), and higher rates of ICU admission (9.5% vs 3.2%, p<0.001). Conclusion In a large multinational federated database, we observed higher mortality, stroke, higher inpatient admissions, and higher rates of ICU admissions among patients with COVID-19 with pancreatitis.
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