Related Experiment Video

Updated: Oct 6, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

725

Long Non-Coding RNAs in Lung Cancer: The Role in Tumor Microenvironment

Shuang Dai1, Ting Liu2, Yan-Yang Liu1

  • 1Department of Medical Oncology, Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in Cell and Developmental Biology
|January 20, 2022
PubMed

Insights

Immune checkpoint inhibitors show promise for lung cancer, but resistance limits effectiveness. This study explores long non-coding RNAs (lncRNAs) within the tumor microenvironment (TME) as potential biomarkers and therapeutic targets for improved lung cancer immunotherapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunotherapy

Background:

  • Immune checkpoint inhibitor (ICI) therapy has improved advanced lung cancer treatment outcomes.
  • However, immunological nonresponse and resistance limit the efficacy and durability of ICI therapy in many patients.
  • Novel biomarkers and therapeutic targets are crucial for advancing lung cancer immunotherapy.

Purpose of the Study:

  • To review the roles of long non-coding RNAs (lncRNAs) in the tumor microenvironment (TME) of lung cancer.
  • To explore the potential of TME-related lncRNAs as biomarkers for precise diagnosis and treatment.
  • To discuss the application of lncRNAs as therapeutic targets for enhancing lung cancer immunotherapy.

Main Methods:

  • Literature review and synthesis of existing research on lncRNAs in the lung cancer TME.
  • Analysis of the functional roles of lncRNAs in immune response and resistance mechanisms.
  • Evaluation of lncRNAs as diagnostic, prognostic, and predictive biomarkers.

Main Results:

  • lncRNAs are integral components of the TME, influencing immune cell infiltration, function, and overall tumor progression.
  • Specific TME-related lncRNAs have demonstrated potential as biomarkers for predicting immunotherapy response.
  • Dysregulation of lncRNAs can contribute to resistance against current immunotherapies.

Conclusions:

  • TME-related lncRNAs represent a promising area for developing novel biomarkers in lung cancer.
  • Targeting lncRNAs offers a potential strategy to overcome immunotherapy resistance and improve patient outcomes.
  • Further research into lncRNA functions and therapeutic applications is warranted for lung cancer immunotherapy.
Keywords:
biomakerimmunotherapylncRNAnon-small cell lung cancertumor microenvironment

More Related Videos

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

6.6K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.0K
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.9K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.2K
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
6.8K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
12.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K