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Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
Published on: January 16, 2015
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Dysregulated Cell Signaling in Pulmonary Emphysema
Chih-Ru Lin1,2, Karim Bahmed2,3, Beata Kosmider1,2
1Department of Microbiology, Immunology, and Inflammation, Temple University, Philadelphia, PA, United States.
Frontiers in Medicine
|January 20, 2022
Summary
Pulmonary emphysema, driven by smoking, involves alveolar wall destruction and airflow limitation. This review details signaling pathway dysregulation, particularly in alveolar type II cells, and discusses potential treatments.
Area of Science:
- Pulmonary Medicine
- Cell Biology
- Pathophysiology
Background:
- Pulmonary emphysema involves alveolar septa destruction and irreversible airflow limitation, primarily caused by cigarette smoking.
- Alveolar type II (ATII) cells, crucial for lung repair, exhibit dysfunction in emphysema, a disease lacking effective treatments.
- Emphysema pathogenesis is complex, involving disrupted signaling pathways, oxidative stress, inflammation, and genetic factors.
Purpose of the Study:
- To comprehensively review studies on dysregulated cell signaling in emphysema, focusing on ATII cells.
- To elucidate the contribution of these signaling pathways to alveolar wall destruction.
- To describe relevant preclinical and clinical interventions for emphysema.
Main Methods:
- Literature review of studies on emphysema pathophysiology and cell signaling.
- Analysis of research on alveolar type II cell function and dysfunction.
- Compilation of data on preclinical and clinical interventions.
Main Results:
- Emphysema is linked to dysregulated signaling pathways, including inflammation, oxidative stress, and proteostasis.
- ATII cell dysfunction significantly contributes to alveolar wall destruction in emphysema.
- Various signaling pathways implicated in emphysema progression are identified.
Conclusions:
- Understanding dysregulated cell signaling in ATII cells is crucial for emphysema research.
- Targeting specific signaling pathways offers potential therapeutic strategies for emphysema.
- Further research into cellular mechanisms and interventions is needed for effective emphysema treatment.
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