Selecting esophageal cancer patients for lymphadenectomy after neoadjuvant chemoradiotherapy: a modeling study
Mirre Scholte1, Didi Jjm de Gouw2, Bastiaan R Klarenbeek2
1Operating Rooms, Radboud Institute of Health Sciences, Radboudumc, Nijmegen, The Netherlands.
Objectives:
Two-thirds of patients do not harbor lymph node (LN) metastases after neoadjuvant chemoradiotherapy (nCRT). Our aim was to explore under which circumstances a selective lymph node dissection (LND) strategy, which selects patients for LND based on the restaging results after nCRT, has added value compared with standard LND in esophageal cancer.
Design:
A decision tree with state-transition model was developed. Input data on short-term and long-term consequences were derived from literature. Sensitivity analyses were conducted to assess promising scenarios and uncertainty.
Setting:
Dutch healthcare system.
Participants:
Hypothetical cohort of esophageal cancer patients who have already received nCRT and are scheduled for esophagectomy.
Interventions:
A standard LND cohort was compared with a cohort of patients that received selective LND based on the restaging results after nCRT.
Main Outcome Measures:
Quality-adjusted life years (QALYs), residual LN metastases and LND-related complications.
Results:
Selective LND could have short-term benefits, that is, a decrease in the number of performed LNDs and LND-related complications. However, this may not outweigh a slight increase in residual LN metastases which negatively impacts QALYs in the long-term. To accomplish equal QALYs as with standard LND, a new surgical strategy should have the same or higher treatment success rate as standard LND, that is, should show equal or less recurrences due to residual LN metastases.
Conclusions:
The reduction in LND-related complications that is accomplished by selecting patients for LND based on restaging results after nCRT seems not to outweigh a QALY loss in the long-term due to residual LN metastases. Despite the short-term advantages of selective LND, this strategy can only match long-term QALYs of standard LND when its success rate equals the success rate of standard LND.
