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The application of radiomics in predicting gene mutations in cancer
Yana Qi1, Tingting Zhao1, Mingyong Han2
1Cancer Therapy and Research Center, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, 324 Jingwuweiqi Road, Jinan, 250021, Shandong, China.
Abstract:
With the development of genome sequencing, the role of molecular targeted therapy in cancer is becoming increasingly important. However, genetic testing remains expensive, invasive, and time-consuming, and thus unavailable for all patients. Radiogenomics aims to correlate imaging characteristics with gene expression patterns, gene mutations, and other genome-related characteristics. Due to the noninvasive nature of medical imaging, the field of radiogenomics is rapidly developing and may serve as a substitute tool for genetic testing. In this article, we briefly summarise the current role of radiogenomics in predicting gene mutations in brain, lung, colorectal, breast, and kidney tumours. KEY POINTS: • The role of molecular targeted therapy in individual cancer-precision therapy is becoming increasingly important with the development of genetic testing. • Radiogenomics may provide accurate imaging biomarkers as a substitute for genetic testing. • While the field of radiogenomics holds great promise, there are still a number of limitations that need to be overcome.
Insights
Radiogenomics uses medical imaging to predict cancer gene mutations, offering a noninvasive alternative to costly genetic testing. This field shows promise for personalized cancer therapy but requires further development to overcome current limitations.
Area of Science:
- Oncology
- Radiology
- Genomics
Background:
- Molecular targeted therapy is crucial for precision cancer treatment, driven by advances in genetic testing.
- Genetic testing is often expensive, invasive, and time-consuming, limiting its accessibility for all cancer patients.
- Radiogenomics emerges as a potential solution by linking imaging features to genomic characteristics.
Purpose of the Study:
- To review the current applications of radiogenomics in predicting gene mutations across various cancers.
- To highlight radiogenomics as a noninvasive tool for cancer genetic profiling.
- To discuss the potential and limitations of radiogenomics in clinical practice.
Main Methods:
- Correlation of imaging characteristics with gene expression patterns and mutations.
- Analysis of radiogenomic data in brain, lung, colorectal, breast, and kidney tumors.
- Review of existing literature on radiogenomics and its predictive capabilities.
Main Results:
- Radiogenomics demonstrates potential in predicting gene mutations noninvasively.
- Imaging biomarkers can be derived to infer genomic status in tumors.
- The field is rapidly advancing, showing promise for personalized medicine.
Conclusions:
- Radiogenomics offers a promising, noninvasive approach to complement or substitute traditional genetic testing in oncology.
- Accurate imaging biomarkers are key to advancing radiogenomics for precision cancer therapy.
- Further research is needed to address limitations and fully integrate radiogenomics into clinical workflows.
