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Development of Compendium for Esophageal Squamous Cell Carcinoma
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Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

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Expression and Significance of N-myc downstream regulated gene 2 in the process of Esophageal Squamous Cell

Rui-Bing Feng1, Qiao-Zhi Zhou1, Rui Cheng1

  • 1Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing, China.

Bioengineered
|January 20, 2022
PubMed

Insights

The tumor suppressor gene NDRG2 expression decreases as esophageal squamous cell carcinoma (ESCC) progresses. Lower NDRG2 levels in advanced ESCC aid in early diagnosis and prognosis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • N-myc downstream-regulated gene 2 (NDRG2) is a tumor suppressor gene.
  • NDRG2 expression is reduced in various human solid tumors, including esophageal squamous cell carcinoma (ESCC).

Purpose of the Study:

  • To investigate NDRG2 expression differences across various stages of ESCC.
  • To establish a basis for early diagnosis and prognosis of ESCC through NDRG2 detection.

Main Methods:

  • Immunohistochemical staining was employed to assess NDRG2 expression levels.
  • NDRG2 expression was analyzed in 91 patient samples: mild-to-moderate dysplasia, early ESCC, and advanced ESCC.
  • Correlation between NDRG2 expression and clinicopathological characteristics was examined.

Main Results:

  • Positive NDRG2 expression rates were significantly higher in mild-to-moderate dysplasia (74.1%), adjacent to early ESCC (76.7%), and early ESCC (83.3%) compared to advanced ESCC (55.9%).
  • A significant decrease in NDRG2 expression was observed with ESCC progression (p < 0.05).
  • NDRG2 expression correlated significantly with clinical stage (Cramer's V = 0.351, p = 0.019).

Conclusions:

  • NDRG2 expression gradually diminishes as esophageal lesions progress to advanced ESCC.
  • NDRG2 detection is crucial for differentiating early ESCC from advanced stages.
  • The observed differences in NDRG2 expression were more pronounced in male patients and those under 60.
Keywords:
ESCCN-myc downstream-regulated gene 2 (NDRG2)clinicopathological characteristicsimmunohistochemical techniques

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