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Multiphysics microfluidics for cell manipulation and separation: a review.

Haotian Cha¹, Hedieh Fallahi¹, Yuchen Dai¹

¹Queensland Micro- and Nanotechnology Centre, Griffith University, Nathan, Queensland 4111, Australia. nam-trung.nguyen@griffith.edu.au.

|January 20, 2022

Summary

This summary is machine-generated.

Multiphysics microfluidics integrates multiple physical forces for advanced cell manipulation. This review explores combining forces like dielectrophoresis (DEP) and magnetophoresis (MP) for enhanced biomedical applications.

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Area of Science:

Biomedical Engineering
Microfluidics
Cellular Manipulation

Background:

Multiphysics microfluidics combines multiple physical processes on a microfluidic platform.
It offers advantages over single-phenomenon approaches for cell manipulation.
Key applications are emerging in diverse biomedical fields.

Purpose of the Study:

To review the state-of-the-art in multiphysics microfluidics.
To reassess the feasibility of coupling multiple physical processes.
To focus on five common microfluidic forces: inertial lift, elastic, dielectrophoresis (DEP), magnetophoresis (MP), and acoustic forces.

Main Methods:

Explanation of working mechanisms for single physical phenomena.
Classification of multiphysics techniques into cascaded connections and physical coupling.
Elaboration on system designs and working mechanisms from existing literature.

Main Results:

Detailed review of single physical phenomena in microfluidics.
Categorization of multiphysics microfluidic systems.
Analysis of combined designs and mechanisms for cell manipulation.

Conclusions:

Multiphysics microfluidics provides high precision, sensitivity, and tunable cell sorting.
Coupling forces like DEP and MP enhances capabilities for biomedical applications.
Future directions involve exploring novel combinations and design schemes for advanced microfluidic systems.