Related Experiment Video

Updated: Oct 6, 2025

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells
11:16

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells

Published on: February 15, 2019

7.8K

Profound thrombocytopenia associated with administration of multiple anti-inflammatory agents in baboons

Mohamed H Bikhet1, Christophe Hansen-Estruch1, Mariyam Javed1

  • 1Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Immunity, Inflammation and Disease
|January 20, 2022
PubMed

Abstract:

Congestion, granular platelet debris both within macrophage and extracellularly, and neutrophil infiltration in the spleen of a baboon that was euthanized with profound thrombocytopenia.

Keywords:
IL-6baboonpigthrombocytopeniaxenotransplantation

More Related Videos

Transient Expression of Proteins by Hydrodynamic Gene Delivery in Mice
12:54

Transient Expression of Proteins by Hydrodynamic Gene Delivery in Mice

Published on: May 5, 2014

28.9K
Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques
11:06

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques

Published on: May 2, 2017

51.3K

Related Experiment Videos

Last Updated: Oct 6, 2025

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells
11:16

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells

Published on: February 15, 2019

7.8K
Transient Expression of Proteins by Hydrodynamic Gene Delivery in Mice
12:54

Transient Expression of Proteins by Hydrodynamic Gene Delivery in Mice

Published on: May 5, 2014

28.9K
Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques
11:06

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques

Published on: May 2, 2017

51.3K

Related Concept Videos

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

701
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
701
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

1.4K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.4K

Articles linked to this work by shared authors, journal, and citation graph.

Early outcomes following multivalve heart operation in octogenarians.

JTCVS open·2026

Treatment of innominate artery during thoracic endovascular aortic repair is associated with higher stroke rate.

JTCVS structural and endovascular·2026

Noninvasive Monitoring of Complement Using the Bioluminescent Modified Ham Assay in the Second Porcine-to-Human Live Heart Transplant.

Xenotransplantation·2026

High levels of IL-6 and IL-8 early after pig-to-nonhuman primate kidney xenotransplantation from α1,3-galactosyltransferase gene-knockout (GTKO) pigs.

Cytokine·2026

Renin-Angiotensin-Aldosterone System (RAAS) in Pig-to-Baboon Kidney Xenotransplantation-Relevance to Clinical Pig Kidney Xenotransplantation.

Xenotransplantation·2026

Investigational New Drug Enabling Nonclinical Study of Xenogeneic Life-Supporting Porcine Kidneys With 10 Gene Edits (10 GE) in a Nonhuman Primate Test System.

Xenotransplantation·2026

Genetic Variants at the NAT2 and HLA-DOA are Associated With Anti-Tuberculosis Drug-Induced Liver Injury Susceptibility and Clinical Manifestations in Western Chinese Populations.

Immunity, inflammation and disease·2026

Gut Microbiota Dysbiosis Mediates 125I-Induced Radiation Colitis via Host Transcriptional Regulation.

Immunity, inflammation and disease·2026

Bushen Huatan Formula Ameliorates Early Chronic Low-Grade Inflammation in Obese PCOS Via the TLR4/NF-κB Signaling Pathway: An Integrated Network Pharmacology and Experimental Study.

Immunity, inflammation and disease·2026

Exploring the Mechanism of Action of Danggui Buxue Decoction in Treating Chronic Glomerulonephritis Based on UPLC-MS/MS and Network Pharmacology.

Immunity, inflammation and disease·2026

Combination Treatment of IL-17 Inhibitor and JAK Inhibitor in Psoriatic Arthritis: A Case Report and Scoping Review.

Immunity, inflammation and disease·2026

Juanbi Tang Attenuates Intervertebral Disc Degeneration by Suppressing p38MAPK/NF-κB Signaling and Activating Atg5-Dependent Autophagy to Promote Macrophage M2 Polarization: In Vivo and In Vitro Evidence.

Immunity, inflammation and disease·2026

Exploratory Analysis of Thromboinflammatory and Hematological Changes Following Electrolytic Femoral Vein Injury in Wistar Rats.

Cureus·2026

Correction: Li et al. Balancing Reproduction and Survival: Seasonal Body Mass Dynamics in a High-Altitude Primate (Rhinopithecus bieti). Animals 2026, 16, 1603.

Animals : an open access journal from MDPI·2026

Whole-mount diffracted X-ray blinking analysis of intracellular amyloid-β-associated nanoscale dynamics in Caenorhabditis elegans.

Biology methods & protocols·2026

Calu-3 cells as novel efficient cell culture system for Borna disease virus 1 (BoDV-1).

Virus research·2026

Imaging cellular activity across all organs reveals body-wide circuits.

Nature·2026

Diagnostic Value of Tubomanometry in Patulous Eustachian Tube.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us