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Updated: Oct 6, 2025

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
Published on: March 22, 2018
Is replication possible without fidelity?
Michelle R Ellefson1, Daniel M Oppenheimer2
1Faculty of Education, University of Cambridge.
Abstract:
Failure of replication attempts in experimental psychology might extend beyond p-hacking, publication bias or hidden moderators; reductions in experimental power can be caused by violations of fidelity to a set of experimental protocols. In this article, we run a series of simulations to systematically explore how manipulating fidelity influences effect size. We find statistical patterns that mimic those found in ManyLabs style replications and meta-analyses, suggesting that fidelity violations are present in many replications attempts in psychology. Scholars in intervention science, medicine, and education have developed methods of improving and measuring fidelity, and as replication becomes more mainstream in psychology, the field would benefit from adopting such approaches as well. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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