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Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
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Safe and Effective Use of Imatinib to Treat Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia During

Sarah Ashraf1, Julie Wolfson2, Pankit Vachhani3

  • 1The Aga Khan University-Medical College, Karachi, Pakistan.

Journal of Adolescent and Young Adult Oncology
|January 20, 2022
PubMed

Philadelphia chromosome positive (Ph+) B cell acute lymphoblastic leukemia (ALL) is extremely rare in pregnancy. Although the use of tyrosine kinase inhibitors (TKIs) has significantly improved outcomes of patients with Ph+ ALL, its use during pregnancy is not recommended due to the risk of fetal malformations. There are limited data on the use of TKIs during pregnancy and its long-term effects on the fetus. Within this context, we present a case of a 25-year-old woman diagnosed with Ph+ ALL during the third trimester and the safe and effective use of imatinib as treatment after failure of conventional chemotherapy.

Keywords:
Philadelphia chromosome positiveacute lymphoblastic leukemiaimatinibpregnancy

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