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Urine-Derived Stem Cells for Regenerative Medicine: Basic Biology, Applications, and Challenges
Yi-Zhou Huang1, Tao He1,2, Jing Cui1
1Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
Tissue Engineering. Part B, Reviews
|January 20, 2022
Summary
Human urine-derived stem cells (USCs) offer a promising, non-invasive source for regenerative medicine due to their easy isolation and differentiation potential. Further research is needed to overcome challenges for clinical translation of USC-based therapies.
Area of Science:
- Regenerative Medicine
- Stem Cell Biology
- Urology
Background:
- Stem cell research offers advanced healthcare potential.
- Human urine-derived stem cells (USCs) are a novel, easily accessible cell source.
- USCs exhibit properties similar to mesenchymal stem cells, including paracrine effects and immunomodulation.
Purpose of the Study:
- To provide a comprehensive review of urine-derived stem cell (USC) biology.
- To summarize recent advances in USC applications for tissue regeneration.
- To discuss challenges hindering the clinical translation of USC-based therapies.
Main Methods:
- Literature review of studies on urine-derived stem cells (USCs).
- Analysis of USC isolation, expansion, differentiation, and therapeutic potential.
- Evaluation of preclinical and potential clinical applications of USCs.
Main Results:
- USCs are easily isolated non-invasively, are highly expandable, and can differentiate into multiple lineages.
- USCs demonstrate significant potential in preclinical models for genitourinary regeneration, musculoskeletal repair, and wound healing.
- USCs possess potent paracrine effects and immunomodulatory capabilities.
Conclusions:
- Human urine-derived stem cells (USCs) represent a valuable resource for regenerative medicine.
- USC-based therapies show promise across various regenerative applications.
- Addressing current challenges is crucial for the successful clinical translation of USC therapies.
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