Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Area of Science:

• Biomaterials Science
• Surface Chemistry
• Immunology

Background:

• Nonspecific protein adsorption causes material rejection in biological applications.
• Traditional antifouling materials like polyethylene glycol (PEG) have limitations in complex biological environments.
• Zwitterionic materials, with dual charge groups, exhibit enhanced hydration for superior antifouling capabilities.

Purpose of the Study:

• To review the mechanism, structure, preparation, and properties of zwitterionic materials and hydrogels.
• To highlight recent advances in zwitterionic hydrogel applications in biomedicine.
• To discuss the advantages of zwitterionic hydrogels over traditional antifouling materials.

Main Methods:

• Review of literature on zwitterionic material science and hydrogel preparation.
• Analysis of the hydration properties and antifouling mechanisms of zwitterionic materials.
• Compilation of recent biomedical applications of zwitterionic hydrogels.

Main Results:

• Zwitterionic materials possess strong hydration, crucial for effective antifouling.
• Zwitterionic hydrogels demonstrate excellent structural stability and tunable properties.
• These hydrogels show significant potential in overcoming immune rejection and improving biomaterial performance.

Conclusions:

• Zwitterionic hydrogels represent a significant advancement in antifouling biomaterials.
• Their superior properties address the limitations of conventional materials like PEG.
• Zwitterionic hydrogels are poised for widespread use in diverse biomedical applications.