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Artificial Biomimetic Electrochemical Assemblies
Tanja Zidarič1, Matjaž Finšgar2, Uroš Maver1,3
1Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Taborska ulica 8, SI-2000 Maribor, Slovenia.
Biosensors
|January 20, 2022
Summary
Molecularly imprinted polymers (MIPs) offer a stable and selective alternative to natural receptors for biosensor development. This review highlights electrosynthesized MIPs for detecting protein biomarkers using electrochemical methods.
Area of Science:
- Biomolecular Engineering
- Analytical Chemistry
- Materials Science
Background:
- Biosensors are crucial for rapid, selective, and cost-effective detection of biomolecules.
- Natural receptors offer high affinity but lack stability and durability.
- Molecularly imprinted polymers (MIPs) provide a robust alternative using supramolecular chemistry.
Purpose of the Study:
- To review recent advancements in electrosynthesized molecularly imprinted polymers (MIPs).
- To explore analytical applications of MIPs, focusing on protein biomarker detection.
- To discuss electrochemical detection principles and the gate effect in MIP biosensors.
Main Methods:
- Electrosynthesis of molecularly imprinted polymers (MIPs).
- Development of MIP-based biosensor platforms.
- Electrochemical detection strategies for target analytes.
- Investigation of the gate effect in MIP biosensor performance.
Main Results:
- Electrosynthesized MIPs demonstrate high selectivity and stability for biomolecule detection.
- MIPs effectively replace natural receptors, overcoming limitations of durability.
- Successful application of MIP biosensors for detecting protein-based biomarkers.
Conclusions:
- Electrosynthesized MIPs are a promising technology for advanced biosensing applications.
- MIPs offer a durable and selective platform for clinical diagnostics and biological research.
- Further research into electrochemical readouts and MIP behavior can optimize biosensor performance.
