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NIR-II Aggregation-Induced Emission Luminogens for Tumor Phototheranostics
Yonghong Tan1, Peiying Liu1, Danxia Li1
1Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
Biosensors
|January 20, 2022
Summary
Aggregation-induced emission luminogens (AIEgens) offer dual diagnosis and therapy in phototheranostics. Second near-infrared (NIR-II) AIEgens show promise for clinical applications due to their long wavelengths.
Area of Science:
- Materials Science
- Biomedical Engineering
- Nanotechnology
Background:
- Aggregation-induced emission luminogens (AIEgens) are advanced materials for phototheranostics.
- Second near-infrared (NIR-II) emission (1000-1700 nm) offers advantages for clinical phototheranostics.
- AIEgens in the NIR-II range are crucial for precise diagnosis and efficient therapeutics.
Purpose of the Study:
- To review recent advances in phototheranostics using NIR-II AIEgens.
- To discuss strategies for constructing NIR-II AIEgens.
- To explore applications in various theranostic modalities.
Main Methods:
- Literature review of research published in the last 3 years.
- Analysis of AIEgen design strategies for NIR-II emission.
- Categorization of applications in fluorescence imaging-guided photothermal therapy (FLI-guided PTT), photoacoustic imaging-guided photothermal therapy (PAI-guided PTT), and multimodal imaging-guided photodynamic-photothermal therapy (PDT-PTT).
Main Results:
- Several strategies for developing NIR-II AIEgens have been reported.
- NIR-II AIEgens have shown efficacy in FLI-guided PTT, PAI-guided PTT, and combined PDT-PTT therapies.
- These materials enable simultaneous diagnosis and treatment with enhanced performance.
Conclusions:
- NIR-II AIEgens represent a significant advancement in phototheranostics.
- Further research is needed to overcome challenges and realize full clinical potential.
- The field shows great promise for integrated diagnostic and therapeutic applications.
