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Hemocompatibility of hydrogel with polyethyleneoxide chains
1Second Department of Surgery, Nagoya University School of Medicine, Japan.
Journal of Biomaterials Applications
|October 1, 1987
Abstract:
We have synthesized a hydrogel with long polyethyleneoxide (PEO) chains and evaluated its hemocompatibility. The hydrogel significantly suppressed the adsorption of plasma proteins and adhesion of platelets. In addition, the marked retardation of thrombus formation on its surface was recognized. These findings seems to be caused by the volume restriction effects derived from the highly flexible and hydrophilic PEO chains.