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Pathogenesis, Immunology and Management of Dermatophytosis

Shishira R Jartarkar1, Anant Patil2, Yaser Goldust3

  • 1Department of Dermatology, Vydehi Institute of Medical Sciences and Research Centre University-RGUHS, Bengaluru 560066, India.

Journal of Fungi (Basel, Switzerland)
|January 20, 2022
PubMed

Insights

Dermatophyte infections are common and increasingly difficult to treat. This review synthesizes current literature to improve management strategies for these persistent skin and appendage fungal infections.

Area of Science:

  • Mycology
  • Dermatology
  • Infectious Diseases

Background:

  • Dermatophytic infections of the skin and appendages are prevalent globally.
  • Pathogenesis involves a complex interaction between dermatophytes, host defenses, and environmental factors.
  • Rising incidence of recurrent, recalcitrant, and chronic infections presents a significant public health challenge.

Purpose of the Study:

  • To review the current literature on the management of dermatophytoses.
  • To identify gaps in therapeutic recommendations for fungal skin infections.
  • To provide updated guidance for clinicians managing difficult-to-treat dermatophyte cases.

Main Methods:

  • Comprehensive literature search of relevant databases.
  • Systematic review and synthesis of studies on dermatophytosis management.
  • Analysis of treatment outcomes for various therapeutic approaches.

Main Results:

  • Identification of key factors contributing to treatment failure in dermatophytosis.
  • Evaluation of the efficacy of current antifungal therapies.
  • Highlighting emerging treatment strategies and challenges.

Conclusions:

  • Effective management requires a thorough understanding of pathogenesis and host factors.
  • Addressing the rise in chronic and resistant infections necessitates updated therapeutic guidelines.
  • Bridging the gap in recommendations will improve patient outcomes for fungal skin infections.
Keywords:
dermatophytespathogenesistreatment

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