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Updated: Oct 6, 2025
Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
Published on: June 28, 2019
[Intraventricular blood flows and myocardial contractility in impairments of coronary circulation]
V A Sandrikov1, T Iu Kulagina1, L M Kuznetsova1
1Department of Clinical Physiology, Instrumental and Radiologic Diagnosis, Petrovsky National Research Centre of Surgery, Moscow, Russia.
Insights
Myocardial dysfunction in ischemic heart disease impairs blood flow dynamics and reduces cardiac output. Intraventricular flow analysis can predict the success of coronary revascularization procedures.
Area of Science:
- Cardiovascular Medicine
- Echocardiography
- Cardiac Surgery
Background:
- Ischemic heart disease (IHD) affects myocardial function and cardiac output.
- Assessing left ventricular (LV) function is crucial for managing IHD.
- Myocardial revascularization aims to restore blood flow and improve cardiac performance.
Purpose of the Study:
- To evaluate the impact of myocardial dysfunction on intraventricular blood flow in patients with IHD.
- To assess the utility of echocardiographic parameters in predicting the adequacy of coronary revascularization.
- To investigate alterations in myocardial motion velocity and their relationship with cardiac productivity.
Main Methods:
- Echocardiography (Vivid E9) performed pre-operatively, intraoperatively, and post-operatively (10-14 days) in 106 IHD patients and 30 controls.
- Measurements included LV volumes, ejection fraction, cardiac index, and velocity parameters (dVol/dt, dL/dt).
- Myocardial shift velocity (V1, V2, V3) and intraventricular blood flow patterns were analyzed.
Main Results:
- Myocardial dysfunction significantly altered intraventricular flow structure and acceleration, leading to decreased cardiac output.
- Impaired segmental contractility correlated with >20% decrease in myocardial motion velocity vectors.
- Echocardiographic assessment revealed distinct patterns related to post-infarction cardiosclerosis and Q-wave myocardial infarction.
Conclusions:
- Myocardial dysfunction in IHD patients leads to altered intraventricular flow dynamics and reduced cardiac efficiency.
- Echocardiographic assessment of myocardial motion and intraventricular flows can serve as predictors of successful coronary revascularization.
- These findings highlight the importance of detailed echocardiographic analysis for optimizing IHD management.
Abstract:
We examined a total of 106 patients with ischaemic heart disease (mean age - 59±7 years) and 30 apparently healthy people (mean age - 36±4 years). Myocardial revascularization was performed with the help of stenting and coronary artery bypass grafting. The patients with ischaemic heart disease were divided into 2 groups: Group 1 with postinfarction cardiosclerosis and Group 2 without Q-forming myocardial infarction. Echocardiography was performed using the Vivid E9 machine prior to operation, intraoperatively, and 10-14 after the intervention. We registered the end-systolic volume and end-diastolic volume of the left ventricle, ejection fraction, cardiac index. Alterations of velocity were assessed in relation to of the volume of the left ventricle (dVol/dt), length of the ventricle (dL/dt) in systole and diastole, as well as myocardial shift velocity in 3 endocardial regions - basal (V1), middle (V2), apical portions (V3) and interrelationship with intraventricular blood flows. It was determined that myocardial dysfunction leads to impairment of the structure of the flow, change of acceleration, which is accompanied by a decrease in the cardiac productivity. Impairment of segmental contractility of the left ventricle is manifested by a decrease of vectors of myocardial motion velocity by more than 20%. Intraventricular flows in cardiac chambers may serve as predictors of adequacy of correction of coronary pathology.
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