Radical selenation of C(sp3)-H bonds to asymmetric selenides and mechanistic study
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Updated: Oct 6, 2025

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
Published on: October 18, 2019
1College of Chemistry and Chemical Engineering, Yantai University, Yantai, 264005, Shandong, P. R. China. sunk468@nenu.edu.cn.
Abstract:
Selenides are important structural motifs with a broad range of biological activities and versatile transformational abilities. In this study, a novel and mild method was developed for the facile synthesis of asymmetric selenides under metal-free conditions. The key features of this reaction include good functional-group tolerance, the use of readily available reagents and cheap, low-toxicity solvent, and amenability to gram-scale synthesis. The results of preliminary radical-trapping experiments and a kinetic isotope effect study support a radical process.
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