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Acute phase reactant proteins in Buerger's disease: Is it a systemic disease?
Shayan Keramat1, Oguz Karahan2, Malay Patel3
1Hematology Department, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
Vascular
|January 20, 2022
Summary
Buerger's disease (BD) patients show elevated levels of acute phase reactant (APR) proteins, suggesting a systemic inflammatory disorder. Lower albumin levels in active BD patients indicate potential benefits from anti-inflammatory treatments and dietary changes.
Area of Science:
- Vascular Medicine
- Immunology
- Biochemistry
Background:
- Buerger's disease (BD) is a rare occlusive vasculopathy.
- The inflammatory nature of BD requires further investigation into acute phase reactant (APR) proteins.
Purpose of the Study:
- To compare APR protein levels (hsCRP, PTX3, fibrinogen, C3, hepcidin, albumin) in BD patients versus controls.
- To differentiate inflammatory patterns between active and quiescent phases of BD.
Main Methods:
- Evaluated 92 BD patients and 90 controls from Iran and Turkey.
- Diagnoses confirmed by Shionoya's criteria and angiography/CT angiography.
- Categorized patients into active (rest pain, ulcers, gangrene) and quiescent (stable claudication) phases.
Main Results:
- BD patients exhibited significantly higher PTX3, hsCRP, fibrinogen, C3, and hepcidin levels compared to controls.
- Albumin levels were significantly lower in BD patients.
- Active phase BD patients showed higher fibrinogen, C3, hsCRP, and lower albumin than quiescent phase patients.
Conclusions:
- The APR profile in BD suggests a systemic inflammatory disorder rather than atherosclerosis.
- Further trials on anti-inflammatory drugs (NSAIDs, colchicine, corticosteroids) are warranted for BD management.
- Protein-rich diets may benefit active-phase BD patients due to low albumin levels.
Keywords:
Buerger’s diseaseC-reactive proteinThromboangiitis obliteransacute phase reactant proteinsalbumincomplement C3fibrinogenhepcidinpentraxin 3peripheral arterial diseasevasculitisMore Related Videos
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