T₁-independent exchange rate quantification using saturation- or phase sensitive-water exchange spectroscopy

Water Exchange Spectroscopy (WEX) is a direct measurement of the exchange rate k_sw of labile protons from a solute to water in which the exchange time is varied. However the useful information can be masked by the T₁-decay of the solvent pool. We propose Saturation-WEX and Phase Sensitive WEX (PS-WEX) as an extension upon the WEX approach to reduce T₁-masking. Additionally PS-WEX takes advantage of the phase information contained in the WEX signal to improve the dynamic range.

By introducing an additional RF-pulse and fixing the exchange time delay the T₁-dependence of the signal is reduced. By exploiting the phase sensitivity of the WEX pathway the dynamic range can be increased. This approach is validated using simulations as well as phantom measurements.

The improved dynamic range is demonstrated in measurements. The fixed exchange time reduces the influence of the T₁-decay on the signal curve leading to improved fit quality.

Sat-WEX and PS-WEX are an extension to the well established WEX approach with a less complex fit equation and in the case of PS-WEX improved dynamic range, allowing more accurate quantification.