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Influence of the iron chelating agent desferrioxamine on two rat inflammatory models
1Department of Pharmacology, Martin Luther University Halle-Wittenberg, DDR.
Free Radical Research Communications
|January 1, 1986
Abstract:
The carrageenin rat paw edema was dose-dependently inhibited by i.v. and i.m. administration of desferrioxamine, a specific iron chelating agent. Therefore, iron-catalyzed formation of free radicals might be involved in this acute inflammatory reaction. In contrast, no antiinflammatory activity of desferrioxamine could be seen in rat adjuvant arthritis, a model of subacute and chronic inflammation.