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Related Experiment Videos

Plasma sialic acid alterations in neoplastic diseases.

C Dwivedi1, M Dixit, S S Kumar

  • 1College of Pharmacy, South Dakota State University, Brookings 57007.

Journal of Medicine
|January 1, 1987
PubMed
Summary

Plasma sialic acid levels are elevated in cancer patients compared to healthy individuals. This finding suggests sialic acid may serve as a prognostic marker for neoplastic conditions, though not for initial screening.

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Area of Science:

  • Biochemistry
  • Oncology
  • Clinical Chemistry

Background:

  • Neoplastic transformations alter cell glycoproteins, impacting cell surface composition.
  • Changes in cell surface sialic acid levels are observed during cancer development.

Purpose of the Study:

  • To investigate plasma sialic acid levels in various cancer patients and normal volunteers.
  • To assess the potential of plasma sialic acid as a prognostic determinant in neoplastic diseases.

Main Methods:

  • Plasma sialic acid levels were quantified using thiobarbituric acid spectrophotometric methods.
  • Measurements were taken from 124 normal volunteers and patients with various cancers.

Main Results:

  • Mean plasma sialic acid levels were elevated in breast, lung, colon, ovarian, cervix, pancreas, prostate, thyroid, uterine, squamous cell, esophageal, and endometrial cancers compared to controls.

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  • Serial measurements in 15 patients showed correlation between sialic acid levels and disease progression/regression.

    • Conclusions:

    • Plasma sialic acid levels are elevated in patients with diverse neoplastic conditions.
    • While not sensitive enough for cancer screening, plasma sialic acid may function as a prognostic indicator.