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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Systemic Sclerosis: From Pathophysiology to Novel Therapeutic Approaches
Devis Benfaremo1, Silvia Svegliati2, Chiara Paolini2
1Clinica Medica, Department of Internal Medicine, Ospedali Riuniti "Umberto I-G.M. Lancisi-G. Salesi", 60126 Ancona, Italy.
Biomedicines
|January 21, 2022
Summary
Systemic sclerosis (SSc) is a complex autoimmune disease. This review highlights promising therapeutic targets, including those for fibrotic and immune pathways, to improve SSc management.
Area of Science:
- Immunology
- Rheumatology
- Fibrosis Research
Background:
- Systemic sclerosis (SSc) is a chronic, immune-mediated disease.
- Characterized by vascular damage and progressive fibrosis in skin and organs.
- Pathogenesis involves genetic predisposition, environmental triggers, and persistent immune activation.
Purpose of the Study:
- To review emerging therapeutic targets for Systemic Sclerosis.
- Focus on pathways involved in fibrosis and immune dysregulation.
- To inform future clinical management strategies for SSc.
Main Methods:
- Literature review of current research on SSc pathogenesis.
- Analysis of ongoing clinical trials for novel SSc therapies.
- Synthesis of data on molecular pathways and cellular targets.
Main Results:
- Several molecular pathways are under investigation as therapeutic targets.
- Targets include those modulating fibrotic (e.g., TGF-β, mTOR) and metabolic processes.
- Immune system modulators (e.g., IL4/IL13, JAK/STAT) are also promising.
Conclusions:
- Substantial progress in understanding SSc pathogenesis.
- Disease-modifying therapies for SSc are still needed.
- Targeting specific molecular and cellular pathways offers hope for improved SSc treatment.
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