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Serpinin in the Skin.

Cristina Fraquelli1, Jasmine Hauzinger1, Christian Humpel2

  • 1Department of Ophthalmology, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.

Biomedicines
|January 21, 2022
PubMed
Summary

Serpinins, novel peptides from chromogranin A, are found in rat dorsal root ganglia and sensory nerves of the skin. These biologically active peptides may play a significant role in skin function.

Keywords:
dorsal root gangliaserpininskinsubstance P

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Area of Science:

  • Neuroscience
  • Peptide Biology

Background:

  • Serpinins are novel peptides derived from chromogranin A.
  • They exist in three forms: free serpinin, serpinin-RRG, and pGlu-serpinin.

Purpose of the Study:

  • To investigate the presence and origin of serpinins in rat skin.
  • To determine the distribution and localization of serpinins in neural tissues and skin.

Main Methods:

  • Western blot analysis to detect serinin-containing proteins.
  • RP-HPLC and EIA to quantify serinin forms.
  • Immunohistochemistry to assess cellular distribution and colocalization with substance P.

Main Results:

  • Serinin-containing proteins were detected in rat trigeminal and dorsal root ganglia, but not in skin.
  • All three serinin forms were found in dorsal root ganglia, with free serinin predominant in skin.
  • Serinin-positive cells were abundant in dorsal root ganglia, colocalizing with substance P.
  • Serinin immunoreactivity was observed in sensory and autonomic nerves in the skin, often colocalizing with substance P.

Conclusions:

  • Serinin is present in the sensory innervation of the skin.
  • Serinin peptides are constituents of both dorsal root ganglia and skin innervation.
  • The biological activity of serpinins suggests functional significance in the skin.