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Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
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Disturbance of Vancomycin Infusion Flow during Multidrug Infusion: Influence on Endothelial Cell Toxicity

Maryline Drouet1, Elodie Cuvelier1,2, Feng Chai3

  • 1CHU Lille, ULR 7365-GRITA-Groupe de Recherche sur les Formes Injectables et les Technologies Associées, University Lille, F-59000 Lille, France.

Antibiotics (Basel, Switzerland)
|January 21, 2022
PubMed
Abstract

Insights

Vancomycin infusion via a single peripheral intravenous catheter did not significantly alter endothelial cell toxicity due to concentration variations. However, mechanical stress from multi-drug infusions may increase phlebitis risk.

Area of Science:

  • Pharmacology
  • Vascular Biology
  • Drug Delivery

Background:

  • Phlebitis is a frequent complication of vancomycin peripheral intravenous (PIV) infusion.
  • Co-administration of multiple IV drugs through the same catheter may alter vancomycin concentration and endothelial cell exposure.

Purpose of the Study:

  • To investigate the impact of vancomycin concentration variations on endothelial cell toxicity.
  • To simulate multi-drug infusion therapy and assess its effect on vancomycin-induced phlebitis.

Main Methods:

  • Assessed vancomycin toxicity in human umbilical vein endothelial cells (HUVECs) under simulated multi-infusion conditions.
  • Varied vancomycin concentration to mimic drug mass flow changes.
  • Quantified cell viability and analyzed toxicity using the Kruskal-Wallis test.

Main Results:

  • Variations in vancomycin concentration did not significantly affect local endothelial cell toxicity compared to a fixed concentration.
  • Mechanical trauma from simulated multidrug infusions, not concentration changes, may contribute to phlebitis risk.

Conclusions:

  • Vancomycin-induced phlebitis may stem from causes other than drug concentration fluctuations.
  • Further in vitro studies are needed to isolate mechanical stress effects from concentration variations in phlebitis development.
Keywords:
human umbilical vein endothelial cellsin vitro techniquesinfusionsintravenousphlebitissimulationtoxicity testsvancomycin

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