Phytocompound Mediated Blockage of Quorum Sensing Cascade in ESKAPE Pathogens

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Sreejita Ghosh1, Dibyajit Lahiri2, Moupriya Nag2

  • 1Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, Haringhata 741249, West Bengal, India.

Antibiotics (Basel, Switzerland)
|January 21, 2022
PubMed

Insights

Natural compounds can inhibit quorum sensing (QS) in ESKAPE pathogens, offering new anti-biofilm strategies. These QS inhibitors (QSIs) combat drug-resistant bacteria without traditional antibiotics.

Area of Science:

  • Microbiology
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Rising antimicrobial resistance in ESKAPE pathogens necessitates novel therapeutic approaches.
  • Quorum sensing (QS) is a critical bacterial communication system regulating virulence and biofilm formation.
  • QS inhibitors (QSIs) offer a promising antibiotic-alternative strategy by disrupting bacterial pathogenicity.

Purpose of the Study:

  • To review natural compounds with anti-quorum sensing (anti-QS) activity.
  • To explore the mechanisms by which these natural compounds inhibit QS in ESKAPE pathogens.
  • To highlight the potential of natural QSIs in developing new anti-biofilm therapies.

Main Methods:

  • Literature review of pharmacognostical and pharmacological studies.
  • Analysis of identified natural compounds and their anti-QS mechanisms.
  • Focus on compounds targeting QS-regulated genes in ESKAPE pathogens.

Main Results:

  • A diverse range of natural compounds exhibit significant anti-QS effects.
  • These compounds effectively inhibit QS mechanisms crucial for bacterial pathogenesis.
  • Natural QSIs demonstrate potential in combating ESKAPE pathogens and preventing biofilm formation.

Conclusions:

  • Natural compounds represent a valuable resource for developing novel anti-QS agents.
  • Targeting QS with natural QSIs is a viable strategy to combat drug-resistant ESKAPE pathogens.
  • Further research into natural compound structures can lead to more effective anti-biofilm therapies.
Keywords:
ESKAPE pathogensQS inhibitorsbacterial pathogenesisquorum sensing

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