Related Experiment Video
Updated: Oct 6, 2025
09:51
Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
Published on: May 25, 2018
34.5K
Genome Editing among Bioethics and Regulatory Practices.
1Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 213/D, 41125 Modena, Italy.
Biomolecules
|January 21, 2022
Summary
Genome editing shows promise for genetic diseases, but ethical debates lag behind. Factors beyond 100% effectiveness, like accessibility and acceptability, are crucial for bioethical acceptance.
Area of Science:
- Genetics and Bioethics
- Human Health and Evolution
Background:
- Genome editing technologies have advanced significantly in the past decade.
- Clinical trials are underway for treating genetic diseases using these powerful tools.
Observation:
- Despite decades of discussion, bioethical and regulatory frameworks for genome editing remain underdeveloped.
- There's an overemphasis on technological effectiveness, overshadowing other critical ethical considerations.
Findings:
- The effectiveness of genome editing is a primary focus for regulatory approval.
- Bioethical acceptance is hindered by factors beyond mere technical success, including accessibility and societal acceptability.
Implications:
- Current regulatory approaches may not adequately address the complex bioethical landscape of genome editing.
- Future ethical and regulatory discussions must broaden their scope to include accessibility and acceptability for responsible innovation.
Related Concept Videos
01:59CRISPR
53.3K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
53.3K
00:49What is Genetic Engineering?
76.0K
Overview
76.0K
02:53CRISPR and crRNAs
17.7K
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
17.7K
01:28CRISPR/Cas9 Genome Editing
537
The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
537
01:16In-vitro Mutagenesis
14.9K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
14.9K
02:23RNA Editing
9.2K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.2K