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Point Mutations at a Key Site Alter the Cytochrome P450 OleP Structural Dynamics

Linda Celeste Montemiglio1, Elena Gugole2, Ida Freda2

  • 1Institute of Molecular Biology and Pathology, CNR c/o Department of Biochemical Sciences "A. Rossi Fanelli", University of Rome, Sapienza, P.le A. Moro 5, 00185 Rome, Italy.

Biomolecules
|January 21, 2022
PubMed
Summary

Investigating a cavity in cytochrome P450 OleP reveals its crucial role in substrate binding. Modifying this cavity impacts enzyme activity and offers potential for redirecting OleP

Keywords:
MD simulationOlePP450 structural dynamicsX-ray crystallographyconformational spacecytochrome P450site directed mutagenesis

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