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Nrf2-Related Therapeutic Effects of Curcumin in Different Disorders
Soudeh Ghafouri-Fard1, Hamed Shoorei2, Zahra Bahroudi3
1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 16666-63111, Iran.
Abstract:
Curcumin is a natural polyphenol with antioxidant, antibacterial, anti-cancer, and anti-inflammation effects. This substance has been shown to affect the activity of Nrf2 signaling, a pathway that is activated in response to stress and decreases levels of reactive oxygen species and electrophilic substances. Nrf2-related effects of curcumin have been investigated in different contexts, including gastrointestinal disorders, ischemia-reperfusion injury, diabetes mellitus, nervous system diseases, renal diseases, pulmonary diseases, cardiovascular diseases as well as cancers. In the current review, we discuss the Nrf2-mediated therapeutic effects of curcumin in these conditions. The data reviewed in the current manuscript indicates curcumin as a potential activator of Nrf2 and a therapeutic substance for the protection of cells in several pathological conditions.
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