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Clinical Significance and Regulation of ERK5 Expression and Function in Cancer

Matilde Monti1, Jacopo Celli2, Francesco Missale1,3

  • 1Department of Molecular and Translational Medicine, University of Brescia, 25100 Brescia, Italy.

Cancers
|January 21, 2022
PubMed

Insights

Extracellular signal-regulated kinase 5 (ERK5) is crucial in normal cell functions and increasingly implicated in cancer development and progression. This review highlights ERK5

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Oncology

Background:

  • Extracellular signal-regulated kinase 5 (ERK5) is a unique MAPK family member with a significant role in normal cell growth, survival, and differentiation.
  • ERK5 is increasingly recognized for its involvement in inflammatory disorders and various cancers, influencing tumor initiation and progression.

Purpose of the Study:

  • To review the gene expression profile of ERK5 in cancers and its correlation with clinical impact.
  • To evaluate the prognostic value of ERK5 and phosphorylated ERK5 (pERK5) expression in tumors.
  • To summarize ERK5's role in cancer stem-like cell maintenance and the tumor microenvironment.

Main Methods:

  • Literature review of studies investigating ERK5 expression, clinical impact, and prognostic value in cancer.
  • Analysis of gene expression profiles and their correlation with cancer outcomes.
  • Summary of research on ERK5's role in cancer stemness and the tumor microenvironment.

Main Results:

  • ERK5 expression profiles correlate with clinical impact across various cancers.
  • ERK5 and pERK5 levels serve as potential prognostic markers in tumors.
  • ERK5 is vital for maintaining cancer stem-like phenotypes and influences the tumor microenvironment.

Conclusions:

  • ERK5 plays a significant role in cancer initiation, progression, and the tumor microenvironment.
  • ERK5 and its isoforms represent potential therapeutic targets for cancer treatment.
  • Further research into ERK5's molecular regulation and alternative splicing is warranted for clinical applications.
Keywords:
ERK5alternative splicingcancercancer-stem cellsprognostic markerstumor microenvironment

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