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Hyperuricemia and Associated Factors in Children with Chronic Kidney Disease: A Cross-Sectional Study
Jie Xu1, Lingxiao Tong1, Jianhua Mao1
1Department of Nephrology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, #57 Zhugan Lane, Hangzhou 310003, China.
Insights
High serum uric acid (SUA) is linked to kidney risk factors in children with chronic kidney disease (CKD). Monitoring SUA, hemoglobin (Hb), blood urea nitrogen (BUN), and serum creatinine (Scr) may help slow CKD progression.
Area of Science:
- Pediatric Nephrology
- Urology
- Internal Medicine
Background:
- Hyperuricemia is an emerging risk factor for chronic kidney disease (CKD) in adults.
- Understanding hyperuricemia's role in pediatric CKD is crucial for early intervention.
- This study focuses on clinical characteristics and associated factors of hyperuricemia in Chinese children with CKD.
Purpose of the Study:
- To investigate the clinical characteristics of hyperuricemia in Chinese children diagnosed with CKD.
- To identify factors associated with elevated serum uric acid (SUA) levels in this pediatric population.
- To provide insights for managing hyperuricemia in pediatric CKD patients.
Main Methods:
- A cross-sectional study involving 170 children with CKD from a single pediatric nephrology center.
- Retrospective analysis of clinical data, including anthropometrics, blood pressure, and biochemical parameters.
- Statistical evaluation using Pearson and Spearman correlation, and multiple logistic regression to identify associated factors.
Main Results:
- Significant associations were found between higher serum uric acid (SUA) and elevated blood urea nitrogen (BUN), serum creatinine, cystatin C, and D-dimer.
- Lower hemoglobin, albumin, and estimated glomerular filtration rate (eGFR) were also linked to higher SUA.
- Anemia and higher BUN were positively associated with hyperuricemia, while higher eGFR was negatively associated.
Conclusions:
- Serum uric acid (SUA) is significantly associated with key kidney risk factors in children suffering from CKD.
- Monitoring and managing SUA, hemoglobin (Hb), blood urea nitrogen (BUN), and serum creatinine (Scr) are vital for potentially slowing CKD progression in children.
- This research highlights the importance of a comprehensive approach to managing pediatric CKD.
Background:
Hyperuricemia is increasingly recognized as a risk factor for chronic kidney disease (CKD) just in adults. The purpose of this study was to investigate the clinical characteristics of hyperuricemia and its associated factors in Chinese children with CKD at a single center.
Methods:
A cross-sectional study of 170 CKD children collected from the Department of Nephrology, The Zhejiang University Children's Hospital was conducted. The clinical data, including anthropometric data, blood pressure measurements, and biochemical parameters, were recorded and analyzed retrospectively. The factors associated with hyperuricemia in CKD children were evaluated by Pearson and Spearman correlation analysis and multiple logistic regression analysis.
Results:
The mean age was 9.79 ± 4.10 years, and 72 (42.35%) were girls. Higher blood urea nitrogen (BUN), serum creatinine, cystatin C, D-dimer, lower hemoglobin, albumin, and estimated glomerular filtration rate (eGFR) were significantly associated with higher serum uric acid (SUA). In multiple logistic regression analysis, anemia and higher BUN were both positively associated factors, whereas eGFR ≥ 90 mL/min/1.73 m2 was a negatively associated factor for subjects with SUA ≥ 390 µmol/L (6.5 mg/dL).
Conclusions:
SUA was significantly associated with kidney risk factors in CKD children. Monitoring and controlling SUA, Hb, BUN, and Scr levels in CKD children may help to prevent the progression of CKD.
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