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Pediatric Urachal Anomalies: Monocentric Experience and Mini-Review of Literature
Matthias Nissen1, Phillip Rogge1, Volker Sander1
1Department of Pediatric Surgery, Marien Hospital Witten, St. Elisabeth Group, Ruhr-University of Bochum, Marienplatz 2, D-58452 Witten, Germany.
Insights
Infants under one year old with urachal anomalies (UA) experience fewer complications, suggesting non-surgical management may be viable. Further research is needed to confirm if watchful waiting for spontaneous urachal obliteration is a safe alternative to surgery.
Area of Science:
- Pediatric Surgery
- Urology
- Developmental Biology
Background:
- Urachal anomalies (UA) are typically managed surgically.
- Emerging evidence suggests spontaneous resolution of UA may occur within the first year of life.
- This study investigates age-specific patterns in symptomatic UA to support non-surgical approaches.
Purpose of the Study:
- To identify age-specific patterns in symptoms and outcomes of surgically treated urachal anomalies.
- To evaluate if findings support the potential for non-surgical management of urachal anomalies.
- To analyze the relationship between age and complication rates in pediatric urachal anomalies.
Main Methods:
- Retrospective review of 52 children (<17 years) with symptomatic UA treated surgically (2006-2017).
- Data stratified by age: <1 year (n=35) vs. >1 year (n=17).
- Analysis of complicated (abscess, peritonitis) vs. non-complicated courses.
Main Results:
- Children <1 year old constituted the majority (67%) and had lower complication rates.
- Complicated surgical courses occurred exclusively in patients >1 year old (p=0.003).
- Abdominal pain and leukocytosis were significantly associated with complicated courses in older children.
Conclusions:
- Symptomatic urachal anomalies exhibit an age-dependent complication pattern, with lower rates in infants <1 year.
- These findings suggest that non-surgical management, including watchful waiting, may be a viable option for younger infants.
- Larger studies are warranted to confirm the safety and efficacy of non-surgical management for urachal anomalies.
Background:
Surgery is the current mainstay for the treatment of urachal anomalies (UA). Recent literature data support the theory of a spontaneous resolution within the first year of life. The aim of this study, comprising solely surgically treated children, was to identify age specific patterns regarding symptoms and outcomes that may support the non-surgical treatment of UA.
Methods:
Retrospective review on the clinico-laboratory characteristics of 52 children aged < 17 years undergoing resection of symptomatic UA at our pediatric surgical unit during 2006-2017. Data was dichotomized into age > 1 (n = 17) versus < 1 year (n = 35), and complicated (pre-/post-surgical abscess formation or peritonitis, n = 10) versus non-complicated course (n = 42).
Results:
Children aged < 1 year comprised majority (67%) of cohort and had lower complication rates (p = 0.062). Complicated course at surgery exclusively occurred in patients aged > 1 year (p = 0.003). Additionally, complicated group was older (p = 0.018), displayed leukocytosis (p < 0.001) and higher frequencies regarding presence of abdominal pain (p = 0.008) and abdominal mass (p = 0.034) on admission. Regression analysis identified present abdominal pain (OR (95% CI), 11.121 (1.152-107.337); p = 0.037) and leukocytosis (1.435 (1.070-1.925); p = 0.016) being associated with complicated course.
Conclusions:
This study provides evidence that symptomatic disease course follows an age-dependent complication pattern with lower complication rates at age < 1 year. Larger, studies have to clarify, if waiting for spontaneous urachal obliteration during the first year of life comprises a reasonable alternative to surgery.
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