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Prevalence and Clinical Characteristics of Patients with Pause-Dependent Atrioventricular Block

Sok-Sithikun Bun1, Florian Asarisi1, Nathan Heme1

  • 1Cardiology Department, Pasteur University Hospital, Côte-d'Azur University, 06000 Nice, France.

Journal of Clinical Medicine
|January 21, 2022
PubMed

Insights

Pause-dependent atrioventricular block (PD-AVB) affects 14% of patients with complete atrioventricular block (AVB). PD-AVB is linked to a higher incidence of syncope, underscoring its clinical significance.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Internal Medicine

Background:

  • Complete atrioventricular block (AVB) is a serious cardiac condition.
  • The prevalence and characteristics of pause-dependent atrioventricular block (PD-AVB) in AVB patients remain unclear.

Purpose of the Study:

  • To determine the prevalence of PD-AVB in patients with complete or high-grade AVB.
  • To investigate the clinical characteristics associated with PD-AVB.

Main Methods:

  • Prospective collection of electrocardiogram (ECG) and telemonitoring data from 100 patients with complete (or high-grade) AVB.
  • ECG analysis by an electrophysiologist to identify PD-AVB mechanisms.

Main Results:

  • 14% of patients (14 out of 100) were diagnosed with PD-AVB.
  • PD-AVB patients had a significantly higher rate of syncope (86%) compared to non-PD-AVB patients (51%).
  • Common triggers for PD-AVB included premature atrial contractions and premature ventricular contractions.

Conclusions:

  • The prevalence of PD-AVB in complete AVB is approximately 14%, potentially underestimated.
  • Syncope is a more frequent symptom in patients with PD-AVB.
Abstract

Keywords:
high-grade atrioventricular blockpacemakerpause-dependent atrioventricular blockprevalencesyncope

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