Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

719
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
719
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

513
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
513
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

227
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
227

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of hypercapnic acute respiratory failure with high-flow nasal cannula therapy: A narrative review.

Annals of intensive care·2026
Same author

Relation between initial hypothermia, course of the hypothermia and mortality in patients with septic shock: a post-hoc analysis of the SEPSISPAM randomized trial.

Annals of intensive care·2026
Same author

Prognosis of critically ill patients with severe acute kidney injury and high circulating dipeptidyl peptidase 3: a post hoc analysis of the AKIKI 2 trial.

Critical care (London, England)·2026
Same author

Neutrophils, not macrophages, aid phage-mediated control of pulmonary <i>Pseudomonas aeruginosa</i> infection.

Frontiers in immunology·2025
Same author

Use of rescue noninvasive ventilation for post-extubation respiratory failure.

Critical care (London, England)·2025
Same author

Total liquid ventilation in a porcine model of severe acute respiratory distress syndrome using a new generation of liquid ventilator.

Intensive care medicine experimental·2025

Related Experiment Video

Updated: Oct 6, 2025

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
09:49

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Published on: November 18, 2022

2.3K

Lung Microbiome in Critically Ill Patients.

Mélanie Fromentin1,2, Jean-Damien Ricard2,3, Damien Roux3,4

  • 1Anesthesiology and Intensive Care Department, AP-HP, Hôpital Cochin, 75014 Paris, France.

Life (Basel, Switzerland)
|January 21, 2022
PubMed
Summary

The lung microbiome is diverse, but mechanical ventilation and acute respiratory distress syndrome cause harmful dysbiosis. Understanding these microbial shifts is key to developing new treatments for lung infections.

Keywords:
16S rRNA geneacute respiratory distress syndromedysbiosishigh-throughput sequencinglung microbiomelung mycobiotalung viromemechanical ventilationmetagenomicsventilator-associated pneumonia

More Related Videos

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

3.0K
Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
06:43

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways

Published on: January 13, 2016

9.0K

Related Experiment Videos

Last Updated: Oct 6, 2025

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
09:49

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Published on: November 18, 2022

2.3K
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

3.0K
Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
06:43

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways

Published on: January 13, 2016

9.0K

Area of Science:

  • Microbiology
  • Pulmonology
  • Host-Microbiome Interactions

Background:

  • The lungs, once thought sterile, harbor a diverse microbiome linked to respiratory health.
  • Mechanical ventilation rapidly alters the lung microbiome, decreasing diversity and promoting pathogen growth.
  • Acute respiratory distress syndrome is associated with an increase in gut-origin bacteria.

Purpose of the Study:

  • To review the current understanding of lung microbiome dysbiosis in acute respiratory conditions.
  • To highlight the gaps in knowledge regarding the role of the microbiome in ventilator-associated pneumonia and acute respiratory distress syndrome.
  • To emphasize the need for further research into microbial interactions and host responses.

Main Methods:

  • Literature review of studies on lung microbiome alterations.
  • Analysis of bacterial populations in mechanically ventilated patients and those with acute respiratory distress syndrome.
  • Identification of knowledge gaps concerning viral, fungal, and prokaryotic microbial communities.

Main Results:

  • Pulmonary dysbiosis is a significant factor in chronic and acute respiratory diseases.
  • Mechanical ventilation leads to a decline in microbial diversity and the rise of specific pathogens.
  • Specific bacterial groups, like Proteobacteria and Enterobacteriaceae, are associated with ventilator-associated pneumonia and acute respiratory distress syndrome.

Conclusions:

  • The role of lung dysbiosis in ventilator-associated pneumonia and acute respiratory distress syndrome pathogenesis requires further investigation.
  • Exploring other microbial kingdoms (viruses, fungi) and host-microbiome interactions is crucial.
  • Standardized methodologies are needed for comparative microbiome research to develop effective therapies.