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Improving Isolation of Extracellular Vesicles by Utilizing Nanomaterials.
Haiyang Zhang1, Qi Zhang1, Yuanyuan Deng2
1College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
Membranes
|January 21, 2022
Summary
Extracellular vesicles (EVs), crucial for cell communication and disease biomarker discovery, can be efficiently isolated using nanomaterials. This review highlights advancements in nanomaterial-based EV isolation techniques from 2017-2021.
Area of Science:
- Biotechnology
- Nanotechnology
- Cell Biology
Background:
- Extracellular vesicles (EVs) are key mediators of intercellular communication.
- EVs are found in biofluids and hold potential as biomarkers for disease diagnosis, prognosis, and treatment.
- Efficient isolation of EVs is critical for their clinical application.
Purpose of the Study:
- To review the progress of nanomaterial-based extracellular vesicle (EV) isolation methods from 2017 to 2021.
- To discuss the mechanisms underlying nanomaterial-based EV isolation.
- To provide insights for designing novel nanomaterials for enhanced EV isolation.
Main Methods:
- Literature review of nanomaterial-based EV isolation techniques published between 2017 and 2021.
- Analysis of isolation mechanisms based on nanomaterial properties and interactions with EVs.
- Synthesis of information on the efficiency, speed, and simplicity of various methods.
Main Results:
- Nanomaterials offer rapid, simple, and efficient methods for EV enrichment from biofluids.
- Diverse nanomaterials leverage various mechanisms for specific and effective EV capture.
- Significant advancements have been made in tailoring nanomaterials for targeted EV isolation.
Conclusions:
- Nanomaterial-based strategies are highly promising for the isolation of extracellular vesicles (EVs).
- Understanding isolation mechanisms is crucial for optimizing nanomaterial design for clinical applications.
- Continued research in this area will facilitate the use of EVs as diagnostic and therapeutic tools.
