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Kidney Damage Caused by Obesity and Its Feasible Treatment Drugs

Meihui Wang1, Zixu Wang1, Yaoxing Chen1

  • 1Neurobiology Laboratory, Department of Basic Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.

International Journal of Molecular Sciences
|January 21, 2022
PubMed

Insights

Obesity significantly worsens chronic kidney disease (CKD). Melatonin shows therapeutic potential for obesity-related kidney injury by reducing inflammation and oxidative stress, offering a new treatment avenue.

Area of Science:

  • Nephrology
  • Metabolic Diseases
  • Pharmacology

Background:

  • Obesity is a global health crisis, increasingly linked to chronic kidney disease (CKD) prevalence.
  • Obesity acts as an independent risk factor for kidney disease, contributing to significant renal pathology.

Purpose of the Study:

  • To review the impact of obesity on kidney disease.
  • To explore potential therapeutic strategies for obesity-induced nephropathy.

Main Methods:

  • Review of existing research on obesity and kidney disease.
  • Analysis of histological changes and pathophysiological mechanisms in obesity-related nephropathy.
  • Evaluation of potential treatments including RAS inhibitors, SGLT2 inhibitors, and melatonin.

Main Results:

  • Obesity-induced renal injury involves glomerular/tubular hypertrophy, glomerulosclerosis, inflammation, altered hemodynamics, insulin resistance, and lipid disorders.
  • Current treatments for obesity-related kidney disease are limited.
  • Melatonin demonstrated protective effects against obesity-induced kidney damage.

Conclusions:

  • Melatonin mitigates kidney damage from obesity by inhibiting inflammation and oxidative stress.
  • Melatonin presents significant therapeutic potential for managing obesity-related kidney disease.
Keywords:
inflammationkidney damagemelatoninobesityoxidative stresstreatment

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