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Updated: Oct 6, 2025

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
The Role of Tumor Microenvironment in the Pathogenesis of Sézary Syndrome
Denis Miyashiro1,2, Bruno de Castro E Souza1, Marina Passos Torrealba3
1Division of Clinical Dermatology, University of São Paulo Medical School, Sao Paulo 05403-900, Brazil.
Abstract:
Sézary syndrome is an aggressive leukemic variant of cutaneous T-cell lymphomas, characterized by erythroderma, lymphadenopathy, and peripheral blood involvement by CD4+ malignant T-cells. The pathogenesis of Sézary syndrome is not fully understood. However, the course of the disease is strongly influenced by the tumor microenvironment, which is altered by a combination of cytokines, chemokines, and growth factors. The crosstalk between malignant and reactive cells affects the immunologic response against tumor cells causing immune dysregulation. This review focuses on the interaction of malignant Sézary cells and the tumor microenvironment.
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