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Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues
Xingzhi Wang1, Nitesh Tewari2, Fuyuki Sato3
1Department of Biochemistry, Nihon University School of Medicine, Tokyo 173-8610, Japan.
Abstract:
Sodium fluoride (NaF) is widely used in clinical dentistry. However, the administration of high or low concentrations of NaF has various functions in different tissues. Understanding the mechanisms of the different effects of NaF will help to optimize its use in clinical applications. Studies of NaF and epithelial cells, osteoblasts, osteoclasts, and periodontal cells have suggested the significant roles of fluoride treatment. In this review, we summarize recent studies on the biphasic functions of NaF that are related to both soft and hard periodontal tissues, multiple diseases, and clinical dentistry.
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