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Reduced Incidence of Stroke in Patients with Gout Using Benzbromarone

Sheng-Wen Niu1,2,3,4, Chi-Chih Hung3,4, Hugo Y-H Lin2,3,4

  • 1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, No. 100, Tzyou 1st Road, Kaohsiung 807, Taiwan.

Journal of Personalized Medicine
|January 21, 2022
PubMed

Insights

Benzbromarone, a uricosuric agent, significantly reduces stroke incidence in gout patients. This study found fewer strokes in benzbromarone users compared to non-users, highlighting its potential protective effect against stroke in this population.

Area of Science:

  • Rheumatology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Gout is a significant risk factor for atherosclerotic events, including stroke and myocardial infarction.
  • Stroke prevalence is notably higher in individuals diagnosed with gout.
  • Uricosuric agents are used to manage gout by lowering uric acid levels.

Purpose of the Study:

  • To investigate the impact of benzbromarone, a uricosuric agent, on the incidence of stroke.
  • To evaluate the efficacy of benzbromarone in mitigating stroke risk within the gout patient population.

Main Methods:

  • Utilized data from the Taiwanese National Health Insurance Registration Database (NHIRD).
  • Established a benzbromarone user cohort of 15,143 patients, matched with non-users from the gout population.
  • Employed Cox proportional hazard regression analysis to assess stroke incidence.

Main Results:

  • Benzbromarone users exhibited a significantly lower incidence of stroke compared to non-users.
  • Hazard ratios for stroke were reduced in male benzbromarone users.
  • Significant reductions in stroke incidence were observed in benzbromarone users aged 40-59 and ≥60 years.

Conclusions:

  • Benzbromarone use is associated with a decreased incidence of stroke in patients with gout.
  • The uricosuric agent benzbromarone demonstrates a protective effect against stroke in the gout population.
  • Findings suggest benzbromarone may be a valuable therapeutic option for stroke prevention in gout patients.

Keywords:
benzbromaronegoutstroke

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