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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Multi-Omics Profiling Approach to Asthma: An Evolving Paradigm.

Yadu Gautam1, Elisabet Johansson1, Tesfaye B Mersha1

  • 1Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.

Journal of Personalized Medicine
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Summary
This summary is machine-generated.

Omics research advances asthma understanding by identifying biomarkers for better disease profiling. However, translating these findings into clinical practice for precision medicine remains a challenge.

Keywords:
asthmaepigenomicsexposomicsgenomicsmachine learningmetabolomicsmulti-omicsproteomicstranscriptomics

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Area of Science:

  • Respiratory Medicine
  • Genetics
  • Biomarker Discovery

Background:

  • Asthma is a complex, multifactorial respiratory disease influenced by genetics and environmental exposures.
  • High-throughput omics approaches have become crucial in asthma research for unbiased biomarker screening.
  • Despite advances, omic-driven endotypes have not yet been translated into clinical asthma management.

Purpose of the Study:

  • To provide an overview of current omics studies in asthma research.
  • To discuss the integration of multi-omics data for asthma.
  • To highlight the potential of omics for precision medicine in asthma.

Main Methods:

  • Review of genomics, transcriptomics, epigenomics, proteomics, exposomics, and metabolomics studies in asthma.
  • Discussion of multi-omics data integration strategies.
  • Analysis of biomarker discovery from omics profiling.

Main Results:

  • Omics approaches enable unbiased screening of potential asthma biomarkers.
  • Integration of multi-omics and clinical data improves asthma risk profiling.
  • Biomarker discovery aids in disease phenotyping and endotyping.

Conclusions:

  • Omics research offers significant potential for advancing asthma management and clinical care.
  • Translating omics findings into clinical practice is key for developing precision medicine approaches for asthma.
  • Further research integrating multi-omics data is needed for improved asthma phenotyping and treatment.