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Post-Exposure Prophylaxis and Methamphetamine Use among Young Sexual Minority Men: The P18 Cohort Study
Elizabeth Kaplun1,2, Richard J Martino1, Kristen D Krause1,3
1Center for Health, Identity, Behavior, and Prevention Studies, Rutgers School of Public Health, Newark, NJ 07102, USA.
Abstract:
Methamphetamine use is associated with increased risk of HIV infection among young sexual minority men (SMM). Post-exposure prophylaxis (PEP) is an effective strategy for individuals who are exposed to HIV, but there is limited research about PEP use among young SMM and its relationship with methamphetamine use. This study analyzes the association between ever PEP use and recent methamphetamine use among young SMM in New York City, using cross-sectional data from the P18 Cohort Study (n = 429). Multivariable logistic regression models were used to assess the association between methamphetamine use and ever PEP use. Compared with those who had not used methamphetamine in the last 6 months, young SMM who did use methamphetamine were significantly more likely to have ever used PEP (AOR = 6.07, 95% CI: 2.10-16.86). Young SMM who had ever used PrEP had 16 times higher odds of ever using PEP (AOR = 16, 95% CI: 7.41-35.95). Those who completed bachelor's degrees were 61% less likely to have ever used PEP (AOR = 0.39, 95% CI: 0.17-0.88). These data suggest that methamphetamine use could increase the risk of HIV infection, highlighting the critical need to target interventions for young SMM who use methamphetamine and are more likely to engage in unprotected intercourse.
Insights
Young sexual minority men who use methamphetamine are more likely to use post-exposure prophylaxis (PEP) for HIV prevention. This highlights the need for targeted HIV prevention interventions for this population.
Area of Science:
- Public Health
- Epidemiology
- Sexual Health
Background:
- Methamphetamine use is linked to higher HIV infection risks in young sexual minority men (SMM).
- Post-exposure prophylaxis (PEP) is crucial for HIV prevention after exposure, but its use in young SMM, especially concerning methamphetamine, is under-researched.
Purpose of the Study:
- To analyze the association between recent methamphetamine use and ever using PEP among young SMM in New York City.
Main Methods:
- Cross-sectional data from 429 participants in the P18 Cohort Study were analyzed.
- Multivariable logistic regression models assessed the relationship between methamphetamine use and ever PEP use.
Main Results:
- Young SMM who used methamphetamine were significantly more likely to have ever used PEP (AOR = 6.07).
- Individuals who ever used pre-exposure prophylaxis (PrEP) had 16 times higher odds of ever using PEP (AOR = 16).
- Higher education (bachelor's degree or higher) was associated with lower odds of ever using PEP (AOR = 0.39).
Conclusions:
- Methamphetamine use in young SMM is associated with increased likelihood of PEP use, suggesting potential higher-risk sexual behaviors.
- Interventions targeting young SMM who use methamphetamine are critical for effective HIV prevention strategies.
