Related Experiment Video
Updated: Oct 6, 2025

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Inclusion Complexes of Rifampicin with Native and Derivatized Cyclodextrins: In Silico Modeling, Formulation, and
Qonita Kurnia Anjani1,2, Juan Domínguez-Robles1, Emilia Utomo1
1Medical Biology Centre, School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
Cyclodextrins (CDs) enhance rifampicin (RIF) solubility and dissolution, improving its antibacterial effectiveness against Staphylococcus aureus. This allows for potentially lower daily RIF doses in treating infections.
Area of Science:
- Pharmaceutical Chemistry
- Drug Delivery Systems
- Physical Chemistry
Background:
- Rifampicin (RIF) is a crucial antibiotic, but its therapeutic efficacy can be limited by poor solubility.
- Cyclodextrins (CDs) are known to form inclusion complexes, potentially improving the physicochemical properties of poorly soluble drugs.
Purpose of the Study:
- To investigate the inclusion complexation of RIF with various cyclodextrins (βCD, HP-βCD, γCD, HP-γCD) at different pH values.
- To characterize the RIF-CD complexes and evaluate their dissolution profiles and antibacterial activity.
- To explore the potential of RIF-CD complexes for improved RIF delivery and efficacy.
Main Methods:
- Phase solubility studies were conducted to determine RIF-CD stoichiometry and complex formation.
- Inclusion complexes were characterized using differential scanning calorimetry, FTIR, PXRD, and SEM.
- In vitro dissolution studies and antibacterial assays against Staphylococcus aureus were performed.
Main Results:
- Phase solubility indicated 1:1 RIF-CD stoichiometry under most conditions.
- RIF-CD inclusion complexes significantly enhanced RIF release (>60% in 2h) compared to pure RIF (<10%).
- Antibacterial activity of RIF-CD complexes showed reduced efficacy compared to pure RIF suspension in some cases.
Conclusions:
- Beta-cyclodextrin (βCD) and gamma-cyclodextrin (γCD) effectively enhance RIF solubility and dissolution.
- RIF-CD complexation improves RIF release, suggesting potential for enhanced therapeutic effect.
- Further research is needed to optimize RIF-CD formulations for improved antibacterial efficacy and reduced dosing.
More Related Videos
10:33Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
Published on: October 26, 2015
05:17Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Related Concept Videos
In Vitro Drug Dissolution: Compendial Testing Models I
Biopharmaceutical Factors Influencing Drug Product Design: Overview
In Vitro Drug Dissolution: Compendial Testing Models II
In Vitro Drug Dissolution: Alternative Methods
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Methods for Studying Drug Absorption: In vitro
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...