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Updated: Oct 6, 2025

Assays for the Identification of Novel Antivirals against Bluetongue Virus
Published on: October 11, 2013
Baloxavir Marboxil: An Original New Drug against Influenza
1Unité de Microbiologie, Chimie Bioorganique et Macromoléculaire, Département de Recherche et Développement du Médicament, Faculté de Pharmacie, Campus Plaine CP 205/5, Université Libre de Bruxelles, 1050 Brussels, Belgium.
Abstract:
Baloxavir marboxil is a new drug developed in Japan by Shionogi to treat seasonal flu infection. This cap-dependent endonuclease inhibitor is a prodrug that releases the biologically active baloxavir acid. This new medicine has been marketed in Japan, the USA and Europe. It is well tolerated (more than 1% of the patients experienced diarrhea, bronchitis, nausea, nasopharyngitis, and headache), and both influenza A and B viruses are sensitive, although the B strain is more resistant due to variations in the amino acid residues in the binding site. The drug is now in post-marketing pharmacovigilance phase, and its interest will be especially re-evaluated in the future during the annual flu outbreaks. It has been also introduced in a recent clinical trial against COVID-19 with favipiravir.
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