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Microfluidic Approaches and Methods Enabling Extracellular Vesicle Isolation for Cancer Diagnostics
Premanshu Kumar Singh1, Aarti Patel2, Anastasia Kaffenes3
1Department of Mechanical and Aerospace Engineering, College of Engineering, The Ohio State University, Columbus, OH 43210, USA.
Micromachines
|January 21, 2022
Summary
Microfluidic technologies offer promising solutions for isolating extracellular vesicles, crucial biomarkers for early cancer detection. This review highlights advancements in microfluidic methods for improved cancer diagnostics and point-of-care testing.
Area of Science:
- Biomedical Engineering
- Molecular Oncology
- Nanotechnology
Background:
- Cancer research has elucidated molecular origins, emphasizing biomarkers for diagnosis.
- Extracellular vesicles are key biomarker carriers, but their isolation is challenging.
- Microfluidics presents a promising avenue for overcoming isolation challenges.
Purpose of the Study:
- To review microfluidic technologies for cancer diagnostics.
- To focus on extracellular vesicle isolation methods.
- To highlight the potential for point-of-care diagnostics.
Main Methods:
- Review of existing microfluidic devices.
- Focus on techniques for extracellular vesicle isolation and purification.
- Analysis of technological advancements in the field.
Main Results:
- Microfluidics-enabled devices show significant potential for extracellular vesicle isolation.
- These technologies can address current challenges in purification and analysis.
- Advancements pave the way for reliable, early cancer diagnostics.
Conclusions:
- Microfluidic technologies are crucial for advancing extracellular vesicle-based cancer diagnostics.
- Improved isolation methods will facilitate clinical applications and point-of-care testing.
- This field holds significant promise for the future of cancer detection.
