Oxidative Stress Markers in Hypertrophic Cardiomyopathy

Area of Science:

• Cardiology
• Biochemistry
• Oxidative Stress Research

Background:

• Hypertrophic cardiomyopathy (HCM) is primarily linked to sarcomere dysfunction.
• Secondary cardiac alterations, including those from oxidative stress, can also contribute to HCM.
• Understanding oxidative-antioxidant balance is crucial for HCM research.

Purpose of the Study:

• To investigate oxidative-antioxidant disturbances in patients with HCM.
• To compare oxidative stress markers between HCM patients and healthy controls.
• To evaluate the predictive power of oxidative stress markers for HCM detection.

Main Methods:

• Enrolled 52 HCM patients and 97 controls, matched for age, BMI, and sex.
• Measured total antioxidant capacity (TAC), total oxidant status (TOS), lipid hydroperoxide (LPH), and malondialdehyde (MDA) in peripheral blood.
• Calculated the oxidative stress index (OSI) as the ratio of TOS to TAC.

Main Results:

• TAC and TOS showed good predictive power for HCM detection (AUC 0.77 and 0.83).
• The OSI demonstrated excellent predictive power for HCM detection (AUC 0.87).
• Lipid peroxidation markers (LPH, MDA) also showed good predictive power (AUC 0.73 and 0.79).

Conclusions:

• TOS, TAC, LPH, and MDA levels are valuable predictors for HCM detection.
• The OSI provides a comprehensive assessment of oxidative stress with excellent predictive capability for identifying HCM.
• Oxidative stress markers play a significant role in the pathophysiology and detection of HCM.